Most cellular processes are orchestrated by macromolecular complexes. These are mainly, but not limited to, protein-protein interactions.

The heterogeneity and large size of these assemblies on one hand and subtle molecular differences with small interacting partners make these systems challenging to study. Mass spectrometry is a versatile tool that can handle all classes of biomolecules and particularly suitable in characterizing macromolecules and their interactions.

Program:

09.00-10.00	Registration and Vendor exhibition with coffee
10.00-10.10	Welcome Jonas Bergquist, Chair of SMSS
10.10-11.00	Membrane protein complexes Carol Robinson, University of Oxford, UK
11.00-11.50	CryoEM structure determination of dynamic macromolecular complexes Hans Hebert, Karolinska Institutet, Sweden
11.50-12.10	From form to function – Studying regulators of amyloid formation with mass spectrometry Michael Landreh, Karolinska Institutet, Sweden
12.10-13.00	Lunch and Vendor exhibition with coffee
13.00-13.40	Structural characterization of CRISPR/cas-associated immunitycomplexes by native mass spectrometry Esther van Duijn, BIOMS, The Netherlands
13.40-14.20	Native structures and complexes in mass spectrometry Frank Sobott, University of Antwerpen, Belgium
14.20-14.40	Structural studies of protein ligand interaction for drug-discovery by hydrogen-deuterium exchange mass spectrometry Juan Astorga-Wells, Karolinska Institutet, Sweden
14.40-15.00	Detection of lysine-specific crosslinks within and between proteinsby LC-MALDI MS/MS Sven Kjellström, Lund University, Sweden
15.00-15.30	Coffee and Vendor exhibition
15.30-15.55	Hydrogen-deuterium exchange for protein structure analysis Robert Tonge, Waters Corporation, UK
15.55-16.20	Genome-wide proteomics-protein relocalization post tyrosine kinase inhibition Janne Lehtiö, Karolinska Institutet, Sweden
16.20-16.45	Annual Proceedings of SMSS